Apl Will Require Larger Studies. However, for Blood 1 a P R I L 2 0 0 6 I V O L U M E 1 0 7 , N U M B E R 7
نویسنده
چکیده
selected patients who cannot tolerate anthracycline—for example those with cardiac dysfunction, older adults with poor performance status, and possibly Jehovah’s Witnesses— ATO (probably still in combination with ATRA) would be a very reasonable alternative to the standard ATRA/chemotherapy. Of interest, in this report, patients were initially enrolled in the study because they could not afford standard therapy since the cost of single-agent ATO was much lower. In countries where cost would prohibit standard treatment of APL, a cheaper ATO, produced under good quality control, would be effective in curing many APL patients. The optimal use of ATO in newly diagnosed APL patients still needs to be established. Regardless, this study demonstrates that ATO is a very active—perhaps even the most active—single agent for treating APL. ■ REFERENCES
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